Journal of the American Chemical Society, Vol.130, No.43, 14058-14058, 2008
Synthesis of beta-, gamma-, and delta-Lactams via Pd(II)-Catalyzed C-H Activation Reactions
Pd(II)-catalyzed intramolecular amination of Sp(2) and Sp(3) C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.