Design of Polymeric Carriers for Cancer-Specific Gene Targeting: Utilization of Abnormal Protein Kinase C alpha Activation in Cancer Cells

Kang JH; Asai D; Kim JH; Mori T; Toita R; Tomiyama T; Asami Y; Oishi J; Sato YT; Niidome T; Jun B; Nakashima H; Katayama Y

Journal of the American Chemical Society, Vol.130, No.45, 14906-14906, 2008

Kang JH, Asai D, Kim JH, Mori T, Toita R, Tomiyama T, Asami Y, Oishi J, Sato YT, Niidome T, Jun B, Nakashima H, Katayama Y

We succeeded in cancer cell specific gene expression by using a polyplex responsive to protein kinase C alpha, which is activated in various types of cancer cells.