Journal of the American Chemical Society, Vol.130, No.51, 17232-17232, 2008
Catalytic Enantioselective Intermolecular Hydroacylation: Rhodium-Catalyzed Combination of beta-S-Aldehydes and 1,3-Disubstituted Allenes
A rhodium(I) catalyst incorporating the Me-DuPhos ligand promotes enantioselective intermolecular hydroacylation between P-S-aldehydes and 1,3-disubstituted allenes. The nonconjugated enone products are obtained in good yields and with high enantioselectivities.