Journal of the American Chemical Society, Vol.130, No.52, 17648-17648, 2008
Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe
Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.