Journal of the American Chemical Society, Vol.130, No.52, 17666-17666, 2008
Complete Switch of Product Selectivity in Asymmetric Direct Aldol Reaction with Two Different Chiral Organocatalysts from a Common Chiral Source
A novel approach for asymmetric synthesis of both enantiomeric aldol products has been developed by designing two different chiral organocatalysts from a readily available, protected cis-diamine compound as a common chiral source. This approach would be very useful from a practical viewpoint.