Journal of the American Chemical Society, Vol.131, No.8, 2900-2905, 2009
Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole
The peptide isosteres (110 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.