Journal of the American Chemical Society, Vol.131, No.14, 5020-5020, 2009
Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold
A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.