Preparation of TiO2-loaded nanocapsules and their sun protection behaviors

Kyong-Hwan Chung; Hyo-Yun Jung; Yong-Wook Lee; Ki-Young Lee

Journal of Industrial and Engineering Chemistry, Vol.16, No.2, 261-266, March, 2010

DOI10.1016/j.jiec.2010.01.039 Export Citation

Preparation of TiO2-loaded nanocapsules and their sun protection behaviors

Kyong-Hwan Chung¹, Hyo-Yun Jung², Yong-Wook Lee³, and Ki-Young Lee^{1, 4, †}

¹Department of Applied Chemical Engineering & Center for Functional Nano Fine Chemicals, Chonnam National University, Gwangju 500-757, South Korea
²Interdisciplinary Program of Perfume and Cosmetic, Chonnam National University, Gwangju 500-757, South Korea
³Natural Chemistry Devision, Chemport Inc., 2-1704 Ace Hightech City, 55-20, Munrea-dong 3-ga, Yeongdeungpo-gu, Seoul 150-834, South Korea
⁴Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University, Gwangju 500-757, South Korea

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Titanium dioxide (TiO2) sol (TS) or TiO2 nanoparticles with chitosan shell were encapsulated to enhance their sun protection abilities. Nanocapsules loaded with TiO2 were evaluated for their ultraviolet (UV) absorption and UV protection rate. The effect of eicosapentaenoic acid (EPA) incorporation into the nanocapsules was examined in relation to UV absorption. The particle size of TiO2 crystallites in TS was below 30 nm, which was considerably smaller than that of a commercial TiO2 (P25 TiO2) particles. In the encapsulation of TiO2 with chitosan, the loading efficiencies of TS were higher than those of P25 TiO2. The sizes of the nanocapsules loaded with TiO2 particles ranged from 30 to 80 nm. The absorption range of irradiation wavelength was enlarged by the incorporation of EPA into the nanocapsules. The TS-loaded nanocapsules exhibited a high UV protection rate of up to 95% to both UV-A and UV-B.

Keywords:Nanocapsules;TiO2 sol;UV protection;Eicosapentaenoic acid;Chitosan

[References]

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[Referenced By]

[Related Articles]

[1] Solar and Ultraviolet Radiation, vol. 55, International Agency for Research on Cancer (IARC) Press, Lyon cedex, 1992.

[2] Green A, Battistutta D, Hart V, Leslie D, Weedon D, Am. J. Epidemiol., 144, 1034 (1996)

[3] Gies PH, Roy CR, Toomey S, McLennan A, Mutat. Res., 422, 15 (1998)

[4] Cengiz E, MS thesis, Anadolu University, Institute of Health Sciences, Eskisehir (2003)

[5] Wissing SA, Muller RH, Int. J. Cosmet. Sci., 23, 233 (2001)

[6] Pei AH, Shen ZW, Yang GS, Mater. Lett., 61, 2757 (2007)

[7] Wissing SA, Mader K, Muller RH, Pharmazie, 10, 783 (2001)

[8] Pruim B, Green A, Aust. J. Dermatol., 40, 14 (1999)

[9] Godwin DA, Kim N, Felton LA, Eur. J. Pharm. Biopharm., 53, 23 (2002)

[10] Egerton TA, Everall NJ, Mattinson JA, Kessell LM, Tooley IR, J. Photochem. Photobiol. A, 193 (2008)

[11] Garner AO, Leibold E, van Ravenzwaay B, Toxicol. in Vitro., 20, 301 (2006)

[12] Anderson MW, Hewitt JP, Spruce SR, in: Lowe NJ, Shaath NA, Pathak MA (Eds.), Broad-spectrum Physical Sunscreens: Titanium Dioxide and Zinc Dioxide, Marcel Dekker Inc., New York, 1997, pp. 353-398.

[13] Villalobos-Hernandez JR, Muller-Goymann CC, Eur. J. Pharm. Biopharm., 60, 113 (2005)

[14] Westesen K, Siekmann B, Int. J. Pharm., 151, 35 (1997)

[15] Mehnert W, Mader K, Avd. Drug Del., 47, 165 (2001)

[16] Yin Y, Lu Y, Gates B, Xia Y, Chem. Mater., 13, 146 (2001)

[17] Strohm H, Sgraja M, Bertling J, Lobmann P, J. Mater. Sci., 38(8), 1605 (2003)

[18] Wang D, Caruso RA, Caruso F, Chem. Mater., 13, 364 (2001)

[19] Strohm H, Lobmann P, J. Mater. Chem., 14, 2667 (2004)

[20] Wang D, Caruso F, Chem. Mater., 14, 1909 (2002)

[21] Shchukin DG, Ustinovich E, Sukhorukov GB, Photochem. Photobiol. Sci., 2, 975 (2003)

[22] Yamashita H, Kawasaki S, Ichihashi Y, Takeuchi M, Harada M, Anpo M, Louis C, Che M, Korean J. Chem. Eng., 15(5), 491 (1998)

[23] Relkin PR, Fabre M, Guicharo E, J. Agric. Food Chem., 52, 6257 (2004)

[24] Lowell S, Shields JE, Powder Surface Area and Porosity, London, Chapman & Hall, 1984, pp. 11-13.