Mechanical and tribological properties of melt-compounded titanium dioxide nanocomposites of atomic-layer-deposition (ALD)-coated polyamide particles and commercial nanofillers were compared. The nanofiller dispersion in the polyamide matrix was studied using transmission electron microscopy showing very different morphology for the ALD-created and the traditional nanocomposites: former appearing as ribbons in the matrix whereas latter composing from spherical clusters. The effect of such morphology change on the specimen's mechanical response subjected to tensile and impact loading was investigated. The results demonstrated that ALD-created nanocomposites possess significantly higher Young's modulus than pure and traditionally filled polyamide matrix. However, transition from ductile to brittle behavior occurs especially for the ALD-created nanocomposites. Notched impact strength experiments supported this, suggesting that the impact strength of ALD-created composites decreased significantly compared to pure polyamide matrix, whereas traditionally melt-compounded nanocomposites showed no significant changes. Furthermore, the tribological properties of the selected specimens were determined and the effect of the nanofiller on the friction and scratching properties of the polyamide matrix is discussed.