Synthesis of Poly(vinyl alcohol) (PVA) Nanofibers Incorporating Hydroxyapatite Nanoparticles as Future Implant Materials

Faheem A. Sheikh; Naseer A. M. Barakat; Muzafar A. Kanjwal; Soo Jin Park; Dae Kwang Park; Hak Yong Kim

Macromolecular Research, Vol.18, No.1, 59-66, January, 2010

DOI10.1007/s13233-009-0111-2 Export Citation

Synthesis of Poly(vinyl alcohol) (PVA) Nanofibers Incorporating Hydroxyapatite Nanoparticles as Future Implant Materials

Faheem A. Sheikh, Naseer A. M. Barakat^{1, †}, Muzafar A. Kanjwal², Soo Jin Park³, Dae Kwang Park⁴, and Hak Yong Kim^{4, †}

Department of Bionano System Engineering, Chonbuk National University, Jeonju, 561-756, Korea
¹Chemical Engineering Department, Faculty of Engineering, El-Minia University, El-Minia, Egypt
²Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, 561-756, Korea
³Center for Healthcare Technology Development, Chonbuk National University, Jeonju, 561-756, Korea
⁴Department of Textile Engineering, Chonbuk National University, Jeonju, 561-756, Korea

E-mail:,

This study examined the mechanical properties of a disc consisting of electrospun poly(vinyl alcohol) (PVA) nanofibers incorporated with high purity hydroxyapatite (HAp) nanoparticles (NPs) for potential hard tissue engineering applications. As HAp NPs are insoluble in a PVA aqueous solution, electrospinning of a colloidal solution was used instead of the conventional process, which is based on completely miscible solutions. The PVA/HAp colloidal solutions were characterized by dynamic light scattering (DLS) and electrophoratic light scattering (ELS), which indicated a unimodal size distribution and negative zeta potential. The physiochemical characterizations confirmed the production of PVA electrospun nanofibers incorporating HAp NPs. To investigate the bioactivity of the produced nanofiber mats, compacted mats with a disc shape were incubated in stimulated body fluid (SBF) at 37 degrees C for 6 days. SEM indicated that the incorporation of HAp strongly activates the precipitation of the apatitelike materials because the HAp NPs act as seeds that accelerate the crystallization of biological HAp from the utilized SBF.

Keywords:electrospinning;nanofibers;nanoparticles;hydroxyapatite;implant

[References]

LeGeros RZ, Calcium Phosphates in Oral Biology and Medicine, Karger, Basel, Switzerland, 1991.
Joschek S, Nies B, Krotz R, Gopferich A, Biomaterials, 21, 1645 (2000)
Xiaoying L, Yongbin F, Dachun G, Wei C, Key Eng. Mater., 342-343, 213 (2007)
Ozawa M, Suzuki S, J. Am. Ceram. Soc., 85(5), 1315 (2002)
Hill CM, An YH, Kang QK, Hartsock LA, Gogolewski S, Gorna K, Macromol. Symp., 253, 94 (2007)
Liao S, Chan CK, Ramakrishna S, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 28, 1189 (2008)
Jung YH, Kim HY, Lee DR, Park SY, Khil MS, Macromol. Res., 13(5), 385 (2005)
Doshi J, Reneker DH, J. Electrostat., 35, 151 (1995)
Jin HJ, Hwang MO, Yoon JS, Lee KH, Chin IJ, Kim MN, Macromol. Res., 13(1), 73 (2005)
Agarwal S, Wendorff JH, Greiner A, Polymer, 49(26), 5603 (2008)
Nie H, Wang CH, J. Control. Release, 120, 111 (2007)
Kim HW, Knowles JC, Kim HE, Biomaterials, 25, 1279 (2004)
Venugopal J, Low S, Choon AT, Sampath KTS, Ramakrishna S, J. Mater. Sci. -Mater. Med., 19, 2039 (2008)
Zhang Y, Jayarama RV, Turki AE, Ramakrishna S, Su B, Lim CT, Biomaterials, 29, 4314 (2008)
Chuang WY, Young TH, Yao CH, Chiu WY, Biomaterials, 20, 1479 (1999)
Qi M, Gu Y, Sakata N, Kim D, Shirouzu Y, Yamamoto C, Hiura A, Sumi S, Inoue K, Biomaterials, 25, 5885 (2004)
Lindemann MK, Encyclopedia of Polymer Science and Engineering, John Wiley & Sons Inc., New York, 1971, Vol. 14, p. 149.
Kim GM, Asran AS, Michler GH, Simon P, Bioinsp. Biomim., 3, 12 (2008)
Fujihara K, Kotaki M, Ramakrishna S, Biomaterials, 26, 4139 (2005)
Kim HW, Lee HH, Knowles JC, J. Biomed. Mater. Res., 79A, 643 (2006)
Kim HW, Song JH, Kim HE, Adv. Funct. Mater., 15(12), 1988 (2005)
Erisken C, Kalyon DM, Wang H, Biomaterials, 29, 4065 (2008)
Barakat NAM, Khalil KA, Sheikh FA, Omran AM, Gaihre B, Khil MS, Kim HY, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 28, 1381 (2008)
Barakat NAM, Khil MS, Omran AM, Sheikh FA, Kim HY, J. Process. Technol., 209, 3408 (2009)
Samuel L, Turek MD, Lippincott JB, Orthopaedics: Principles and Appications, 2nd Edition, 1985, p. 113 and 136.
Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T, J. Biomed. Mater. Res., 24, 721 (1990)
Tomoe K, Norihiko M, Masanobu N, Kenichi K, J. Biomed. Mater. Part A, 39, 486 (1998)
Young TH, Hung CH, J. Biomed. Mater. Part A, 39, 486 (1998)
Lopatin CM, Pizziconi V, Alford TL, Laursen T, Thin Solid Films, 326(1-2), 227 (1998)
JCPDS Card No. 9, 432 (1994).
Nishio Y, Manley RJ, Macromolecules, 21, 1270 (1988)
Briggs D, Seah MP, Practical Surface Analysis, 2nd ed., John Willey & Sons, 1993, Vol. 1, pp. 52-63.
Grim O, Inorg. Chem., 14, 1014 (1975)
Gu YW, Khor KA, Cheang P, Biomaterials, 25, 4127 (2004)
Oyane A, Uchid M, Choong C, Triffitt J, Jones J, Ito A, Biomaterials, 26, 2407 (2005)
Lin K, Chang J, Cheng R, Acta Biomater., 3, 271 (2007)
Feng B, Weng J, Yang BC, Qu SX, Zhang XD, Biomaterials, 24, 4663 (2003)

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[1] LeGeros RZ, Calcium Phosphates in Oral Biology and Medicine, Karger, Basel, Switzerland, 1991.

[2] Joschek S, Nies B, Krotz R, Gopferich A, Biomaterials, 21, 1645 (2000)

[3] Xiaoying L, Yongbin F, Dachun G, Wei C, Key Eng. Mater., 342-343, 213 (2007)

[4] Ozawa M, Suzuki S, J. Am. Ceram. Soc., 85(5), 1315 (2002)

[5] Hill CM, An YH, Kang QK, Hartsock LA, Gogolewski S, Gorna K, Macromol. Symp., 253, 94 (2007)

[6] Liao S, Chan CK, Ramakrishna S, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 28, 1189 (2008)

[7] Jung YH, Kim HY, Lee DR, Park SY, Khil MS, Macromol. Res., 13(5), 385 (2005)

[8] Doshi J, Reneker DH, J. Electrostat., 35, 151 (1995)

[9] Jin HJ, Hwang MO, Yoon JS, Lee KH, Chin IJ, Kim MN, Macromol. Res., 13(1), 73 (2005)

[10] Agarwal S, Wendorff JH, Greiner A, Polymer, 49(26), 5603 (2008)

[11] Nie H, Wang CH, J. Control. Release, 120, 111 (2007)

[12] Kim HW, Knowles JC, Kim HE, Biomaterials, 25, 1279 (2004)

[13] Venugopal J, Low S, Choon AT, Sampath KTS, Ramakrishna S, J. Mater. Sci. -Mater. Med., 19, 2039 (2008)

[14] Zhang Y, Jayarama RV, Turki AE, Ramakrishna S, Su B, Lim CT, Biomaterials, 29, 4314 (2008)

[15] Chuang WY, Young TH, Yao CH, Chiu WY, Biomaterials, 20, 1479 (1999)

[16] Qi M, Gu Y, Sakata N, Kim D, Shirouzu Y, Yamamoto C, Hiura A, Sumi S, Inoue K, Biomaterials, 25, 5885 (2004)

[17] Lindemann MK, Encyclopedia of Polymer Science and Engineering, John Wiley & Sons Inc., New York, 1971, Vol. 14, p. 149.

[18] Kim GM, Asran AS, Michler GH, Simon P, Bioinsp. Biomim., 3, 12 (2008)

[19] Fujihara K, Kotaki M, Ramakrishna S, Biomaterials, 26, 4139 (2005)

[20] Kim HW, Lee HH, Knowles JC, J. Biomed. Mater. Res., 79A, 643 (2006)

[21] Kim HW, Song JH, Kim HE, Adv. Funct. Mater., 15(12), 1988 (2005)

[22] Erisken C, Kalyon DM, Wang H, Biomaterials, 29, 4065 (2008)

[23] Barakat NAM, Khalil KA, Sheikh FA, Omran AM, Gaihre B, Khil MS, Kim HY, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 28, 1381 (2008)

[24] Barakat NAM, Khil MS, Omran AM, Sheikh FA, Kim HY, J. Process. Technol., 209, 3408 (2009)

[25] Samuel L, Turek MD, Lippincott JB, Orthopaedics: Principles and Appications, 2nd Edition, 1985, p. 113 and 136.

[26] Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T, J. Biomed. Mater. Res., 24, 721 (1990)

[27] Tomoe K, Norihiko M, Masanobu N, Kenichi K, J. Biomed. Mater. Part A, 39, 486 (1998)

[28] Young TH, Hung CH, J. Biomed. Mater. Part A, 39, 486 (1998)

[29] Lopatin CM, Pizziconi V, Alford TL, Laursen T, Thin Solid Films, 326(1-2), 227 (1998)

[30] JCPDS Card No. 9, 432 (1994).

[31] Nishio Y, Manley RJ, Macromolecules, 21, 1270 (1988)

[32] Briggs D, Seah MP, Practical Surface Analysis, 2nd ed., John Willey & Sons, 1993, Vol. 1, pp. 52-63.

[33] Grim O, Inorg. Chem., 14, 1014 (1975)

[34] Gu YW, Khor KA, Cheang P, Biomaterials, 25, 4127 (2004)

[35] Oyane A, Uchid M, Choong C, Triffitt J, Jones J, Ito A, Biomaterials, 26, 2407 (2005)

[36] Lin K, Chang J, Cheng R, Acta Biomater., 3, 271 (2007)

[37] Feng B, Weng J, Yang BC, Qu SX, Zhang XD, Biomaterials, 24, 4663 (2003)