A series of poly(omega-pentadecalactone) (PPDL) samples, synthesized by lipase catalysis, were prepared by systematic variation of reaction time and water content. These samples possessed weight-average molecular weights (M-w), determined by multi-angle laser light scattering (MALLS), from 2.5 x 10(4) to 48.1 x 10(4). Cold-drawing tensile tests at room temperature of PPDL samples with M-w between 4.5 x 10(4) and 8.1 x 10(4) showed a brittle-to-ductile transition. For PPDL with M-w of 8.1 x 10(4), inter-fibrillar slippage dominates during deformation until fracture. Increasing M-w above 18.9 x 10(4) resulted in enhanced entanglement network strength and strain-hardening. The high M-w samples also exhibited tough properties with elongation at break about 650% and tensile strength about 60.8 MPa, comparable to linear high density polyethylene (HDPE). Relationships among molecular weight, Young's modulus, stress, strain at yield, melting and crystallization enthalpy (by differential scanning calorimetry, DSC) and crystallinity (from wide-angle X-ray diffraction, WAXD) were correlated for PPDL samples. Similarities and differences of linear HDPE and PPDL molecular weight dependence on their mechanical and thermal properties were also compared. (C) 2010 Elsevier Ltd. All rights reserved.