펙틴/CMC 드레싱의 세가지 유형별 창상에서의 치유효과

임현주; 김학태; 오은정; 최진현; 김한도; 편도기; 이수복; 정동준; 정호윤; Hyun Ju Lim; Hak Tae Kim; Eun Jung Oh; Jin Hyun Choi; Han Do Ghim; Do Gi Pyun; Soo Bok Lee; Dong Jun Chung; Ho Yun Chung

Polymer(Korea), Vol.34, No.4, 363-368, July, 2010

Export Citation

펙틴/CMC 드레싱의 세가지 유형별 창상에서의 치유효과

Effect of Newly Developed Pectin/CMC Dressing Materials on Three Different Types of Wound Model

임현주¹, 김학태², 오은정¹, 최진현¹, 김한도¹, 편도기^{3, 4}, 이수복⁵, 정동준 ³, 정호윤^{2, †}

¹경북대학교 기능물질공학과
²경북대학교 의학과 성형외과
³성균관대학교 고분자시스템공학과
⁴(주)티엔엘 기술연구소
⁵텍산메드테크(주)기술연구소

Hyun Ju Lim¹, Hak Tae Kim², Eun Jung Oh¹, Jin Hyun Choi¹, Han Do Ghim¹, Do Gi Pyun^{3, 4}, Soo Bok Lee⁵, Dong Jun Chung³, and Ho Yun Chung^{2, †}

¹Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, 1370 Sankyuk-dong, Buk-gu, Daegu 702-701, Korea
²School of Medicine, Department of Plastic & Reconstructive Surgery, Kyungpook National University, 50 Samduk 2-ga, Jung-gu, Daegu 700-721, Korea
³Department of Polymer Science and Engineering, Sungkyunkwan University, 300 Chunchun-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Korea
⁴T&L Ltd., Tongsam-ri, Namsa-myun, Chuin-gu, Youngin, Gyeonggi-do 449-884, Korea
⁵R&D Center of Texanmedtech. Co., Ltd., 1700-4 Jeongwang-dong, Ciheung, Gyeonggi-do 429-450, Korea

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초록

창상 회복에 있어 적절한 산성의 환경은 세균의 증식을 막을 뿐만 아니라 세포의 활성도를 증가시키고 섬유아 세포의 증식을 촉진시키며 배열을 고르게 유지하여 결국 성숙된 상피화를 가져오게 된다. 본 연구에서는 펙틴과 CMC의 다양한 조성으로 이루어진 드레싱제를 이용하여 펙틴과 CMC의 조성비와 이에 따른 pH의 변화가 신선창상, 감염창상 및 화상에 있어 창상치유속도, 상피화 정도 및 콜라겐 침착 등에 미치는 영향과 이의 새로운 드레싱 재료로서의 가능성을 알아보기 위해 동물실험을 시행하였다. 실험 결과로부터 pH 4.67인 펙틴/CMC＝16/19 군이 급성창상의 창상회복에 있어 창상의 수축률, 치유율 및 상피화율이 다른 군에 비해 높은 정도를 보여 가장 우수한 창상 치유 효과를 보임을 알 수 있었다.

Adequate acidic environment in wound healing prevents the inflammation of virus, increases the cell activity, promotes cell proliferation and regular rearrangement of fibroblast, and results in matured epithelialization. In this study, we prepared dressing materials consisting of pectin and carboxymethylcellulose (CMC) with varied ratios. These dressing materials showed different pH values according to the composition ratio. The effect of acidity of pectin/CMC dressing materials on wound healing rates, degree of epithelialization, collagen deposition, and so on, in 3 types of wound models (fresh surgical wounds, 3rd degree burn wounds, and infection wounds) were investigated by animal tests. From the results of wound contraction, wound healing, and epithelialization, it can be deduced that dressing material having pectin/CMC ratio of 16/19 (pH 4.67) is most effective among the 3 types of wound models.

Keywords:pectin/CMC;wound healing;dressing materials

[References]

Debra M, Plant Biology, 11, 266 (2008)
Liu LS, Won YJ, Cooke PH, Coffin DR, Fishman ML, Hicks KB, Ma PX, Biomaterials, 25, 3201 (2004)
Boussabir A, Gorecki M, Polim. Med., 17, 147 (1987)
Jo SY, Lim YM, Youn MH, Gwon HJ, Park JS, Nho YC, Shin H, Polym.(Korea), 33(6), 551 (2009)
Harding KG, Morrisn HL, Patel GK, BMJ, 324, 160 (2002)
Chikkane K, Takahashi H, Clin. Dermatol., 13, 299 (1995)
Schneider LA, Korber A, Grabbe S, Dissemond J, Arch. Dermatol. Res., 298, 413 (2007)
Tsukada K, Tokunaga K, Iwama T, Mishima Y, Wounds, 4, 16 (1992)
Dewey JC, US Pat. 0022961 (2010)
LaVan FB, Hunt TK, Clin. Plast. Surg., 17, 443 (1990)
Hanna JR, Giacopelli JA, J. Foot Ankle Surg., 36, 2 (1997)

[Referenced By]

[Related Articles]

[1] Debra M, Plant Biology, 11, 266 (2008)

[2] Liu LS, Won YJ, Cooke PH, Coffin DR, Fishman ML, Hicks KB, Ma PX, Biomaterials, 25, 3201 (2004)

[3] Boussabir A, Gorecki M, Polim. Med., 17, 147 (1987)

[4] Jo SY, Lim YM, Youn MH, Gwon HJ, Park JS, Nho YC, Shin H, Polym.(Korea), 33(6), 551 (2009)

[5] Harding KG, Morrisn HL, Patel GK, BMJ, 324, 160 (2002)

[6] Chikkane K, Takahashi H, Clin. Dermatol., 13, 299 (1995)

[7] Schneider LA, Korber A, Grabbe S, Dissemond J, Arch. Dermatol. Res., 298, 413 (2007)

[8] Tsukada K, Tokunaga K, Iwama T, Mishima Y, Wounds, 4, 16 (1992)

[9] Dewey JC, US Pat. 0022961 (2010)

[10] LaVan FB, Hunt TK, Clin. Plast. Surg., 17, 443 (1990)

[11] Hanna JR, Giacopelli JA, J. Foot Ankle Surg., 36, 2 (1997)