The production and supply of potable water and the disposal of wastewater are among the major challenges of the 21st century. Inadequate supply of potable water, coupled with increasing water demand in developing countries due to rapid population growth and industrialization are among the major reasons for the worsening water situation (1). Desalination of brackish water by reverse osmosis (RO) and nanofiltration (NF) are the leading technologies used in supplying potable water. Typically, these plants operate at 75% product water recovery so that 25% of RO feed water is wasted as concentrated brine. However, the recovery can be increased by processing the primary RO reject water with the aid of selective membrane processes such as a secondary RO or NF unit. Hybrid RO/NF processes were modeled using the membrane manufacturer's software for various membranes and for two specific brackish waters studied (total dissolved solids, TDS=1700 and 3700mg/1). The analyses show that 90% product water recovery is achieved for the low TDS feed water and 88% recovery is achieved for the high TDS feed water using simple, state-of-the-art hybrid membrane systems, and with minimal feed water chemical pre-treatment. It is also shown that the specific energy consumption of the RO system is reduced when it is powered by a stand-alone, on-site fuel cell power plant.