In this work, a comprehensive study on the kinetics of formation and decomposition of peroxyacetic acid in soil-slurry systems is presented. A model of peroxyacetic acid formation and decomposition was developed. It includes the kinetics of formation from hydrogen peroxide and acetic acid, peroxyacetic acid decomposition by hydrolysis and hydrogen peroxide and peroxyacetic acid decomposition due to interactions with soil components. The experimental results were properly described by the proposed model, where all kinetic constants were obtained through independent experiments or by fitting of the experimental data. Three application strategies of the process were compared, showing that the highest peroxyacetic concentration in the system is obtained when the soil is added after equilibrium with acetic acid and hydrogen peroxide is achieved.