Highly ordered two-dimensional SnSBA-15 molecular sieve catalysts with different concentrations of tin species have been synthesized using Pluronic P123 as a structure directing agent under pH-adjusting direct hydrothermal method and have been used for synthesis of nopol by Prins condensation of beta-pinene with paraformaldehyde. The influence of various reaction parameters on this reaction has been investigated. The Prins condensation reaction has also been carried out with different solvents for finding the best solvent with a good catalytic activity. In addition, the Prins condensation of beta-pinene with paraformaldehyde in the presence of propyl cyanide with water has been carried out for the synthesis of nopol, and in this condition the catalytic activity of the catalyst used was not seriously affected. On the basis of all catalytic results, SnSBA-15(5) is found to be a highly active, water-resistant and recyclable heterogeneous catalyst for selective synthesis of nopol. (C) 2009 Elsevier B.V. All rights reserved.