The joint transformation of n-butane and methanol has been studied on catalysts prepared based on HZSM-5 zeolites (with different SiO2/Al2O3 ratios and doped with Ni) and SAPO-18. A methanol/n-butane molar ratio of 3 has been used, which corresponds to an energy-neutral integrated process. The kinetic behaviour of the catalysts has been compared based on C-2-C-4 olefin yield, deactivation by coke deposition for 5 h time on stream and hydrothermal stability by operating in reaction-regeneration cycles. The results show a good performance of the catalyst prepared based on HZSM-5 with SiO2/Al2O3 = 30, which has high levels of acidity and acid strength (>= 120 kJ mol NH3-1). This catalyst allows obtaining 24.4% of C-2-C-4 olefin yield (11.5% of propene), with a selectivity of 43% at 575 degrees C and a space time of 1.1 g(cat) h mol(CH2)(-1). The catalyst fully recovers its initial kinetic behaviour after 10 reaction-regeneration cycles. (C) 2010 Elsevier B.V. All rights reserved.