Flow and reaction in a typical commercial scale autoclave LDPE reactor were modeled by a three-dimensional computational fluid dynamic (CFD) k-epsilon model in order to shed light on the macrosegregation effects that can occur in these reactors. It is shown that the CFD model predicts significant differences from CSTR behavior. Results are discussed in terms of the effects of macro- and microscale inhomogeneities of concentration and temperature on free radical polymerization kinetics. The observed nonidealities in terms of minima in the initiator consumption curves and multiple steady states are explained on the basis of competing turbulent transport and chemical kinetics. Microsegregation effects are shown to be negligible in comparison to macrosegregation effects. Given the fact that the CFD model is based an reactive scalar and energy balances without adjusted parameters in the three-dimensional flow field of the entire reactor, it is tentatively concluded that commercial-scale LDPE vessel reactors can have significant macrosegregation effects beyond a certain steady-state adiabatic operating temperature that is specific to the initiator being used.