The present study addresses the insulin sensitivity in mice deficient in LXR beta (LXR beta(-/-)) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp Wt and LXR beta(-/-) mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and Insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps We show that LXR beta(-/-) mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet Moreover we also observed reduced hepatic inflammation in LXR beta(-/-) mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXR beta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks (C) 2010 Elsevier Inc All rights reserved