pH-Dependent release of blue dextran from carboxymethyl-β-cyclodextrin hydrogels

Xia Yang; Jin-Chul Kim

Journal of Industrial and Engineering Chemistry, Vol.16, No.5, 763-766, September, 2010

DOI10.1016/j.jiec.2010.07.006 Export Citation

pH-Dependent release of blue dextran from carboxymethyl-β-cyclodextrin hydrogels

Xia Yang, and Jin-Chul Kim^†

Division of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1 Hyoja 2 dong, Chunchon,Kangwon-do 200-701, Republic of Korea

E-mail:

Carboxymethyl-β-cyclodextrin (CM-β-CD) hydrogel was prepared by cross-linking β-CD and substituting the hydroxyl groups with carboxymethyl group. Epichlorohydrin (EPI) was used as a cross-linker and the molar ratio of EPI to β-CD was 10:1. The number of carboxymethyl group per β-CD residue was determined by a back-titration method and the value was 0.86. The swelling ratio of CM-β-CD hydrogel increased as the pH of medium increased. The carboxyl group will be ionized with increasing pH and an electrostatic repulsion developed within the hydrogels would be responsible for a higher swelling ratio at a higher pH. The degree of release of blue dextran from the hydrogel also increased as the pH of medium increased. The pH-dependent swelling ratio could account for the pHsensitive release.

Keywords:Carboxymethyl-β-cyclodextrin;Hydrogel;pH-Sensitive release;Swelling ratio

[References]

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Yun J, Kim HI, J. Ind. Eng. Chem., 15(6), 902 (2009)
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Nguyen MK, Huynh CT, Lee DS, Polymer, 50(22), 5205 (2009)
Liu H, Liu M, Jin S, Chen S, Polym. Int., 57, 1165 (2008)
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Yang X, Kim JC, Int. J. Pharm., 388, 58 (2010)
Salmaso S, Semenzato A, Bersani S, Matricardi P, Rossi F, Caliceti P, Int. J. Pharm., 345, 42 (2007)
Hussein K, Tu¨ rk M, Wahl MA, Eur. J. Pharm. Sci., 33, 306 (2008)
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Renard E, Deratani A, Volet G, Sebille B, Eur. Polym. J., 33, 49 (1997)
Fenyvesi E, Ujha´ zy A, Szejtli J, Potter S, Gan TG, J. Incl. Phenom. Macrocycl. Chem., 25, 185 (1996)
Yang CQ, Wang D, Text. Res. J., 70, 615 (2000)
Basappa C, Rao P, Narasimha Rao D, Divakar S, Int. J. Food Sci. Technol., 33, 517 (1998)
Choi JH, Lee HY, Kim JC, J. Appl. Polym. Sci., 110(1), 117 (2008)
Pacios IE, Pastoriza A, Pierola IF, Colloid Polym. Sci., 285, 263 (2006)
Zhang C, Zhao K, Hu T, Cui X, Brown N, Boland T, J. Control. Release., 131, 128 (2008)

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[3] Yun J, Kim HI, J. Ind. Eng. Chem., 15(6), 902 (2009)

[4] Schuetz YB, Gurny R, Jordan O, Eur. J. Pharm. Biopharm., 68, 19 (2008)

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[9] Chung HJ, Lee Y, Park TG, J. Control. Release., 127, 22 (2008)

[10] Chen J, Rong L, Lin H, Xiao RJ, Wu HF, Mater. Chem. Phys., 116(1), 148 (2009)

[11] Zhou Y, Yang D, Ma G, Tan H, Jin Y, Nie J, Polym. Adv. Technol., 19, 1133 (2008)

[12] George M, Abraham TE, Int. J. Pharm., 335, 123 (2007)

[13] Nguyen MK, Huynh CT, Lee DS, Polymer, 50(22), 5205 (2009)

[14] Liu H, Liu M, Jin S, Chen S, Polym. Int., 57, 1165 (2008)

[15] Giannuzzo M, Corrente F, Feeney M, Paoletti L, Paolicelli P, Tita B, Vitali F, Casadei MA, J. Drug Target., 16, 649 (2008)

[16] Rao KSVK, Ha CS, Polym. Bull., 62(2), 167 (2009)

[17] Sutar PB, Mishra RK, Pal K, Banthia AK, J. Mater. Sci. Mater. Med., 19, 2247 (2008)

[18] Huang Y, Yu H, Xiao C, Carbohydr. Polym., 69, 774 (2007)

[19] Wu J, Su ZG, Ma GH, Int. J. Pharm., 315, 1 (2006)

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[21] Salmaso S, Semenzato A, Bersani S, Matricardi P, Rossi F, Caliceti P, Int. J. Pharm., 345, 42 (2007)

[22] Hussein K, Tu¨ rk M, Wahl MA, Eur. J. Pharm. Sci., 33, 306 (2008)

[23] Yang X, Kim JC, Biotechnol. Bioeng., doi:10.1002/bit.22696. (2010)

[24] Renard E, Deratani A, Volet G, Sebille B, Eur. Polym. J., 33, 49 (1997)

[25] Fenyvesi E, Ujha´ zy A, Szejtli J, Potter S, Gan TG, J. Incl. Phenom. Macrocycl. Chem., 25, 185 (1996)

[26] Yang CQ, Wang D, Text. Res. J., 70, 615 (2000)

[27] Basappa C, Rao P, Narasimha Rao D, Divakar S, Int. J. Food Sci. Technol., 33, 517 (1998)

[28] Choi JH, Lee HY, Kim JC, J. Appl. Polym. Sci., 110(1), 117 (2008)

[29] Pacios IE, Pastoriza A, Pierola IF, Colloid Polym. Sci., 285, 263 (2006)

[30] Zhang C, Zhao K, Hu T, Cui X, Brown N, Boland T, J. Control. Release., 131, 128 (2008)