The solubilities of norfloxacin in ethanol, 1-propanol, acetone, and chloroform have been determined from 294.15 to 318.15 K by a static equilibrium method. The experimental results showed that the solubilities of norfloxacin in ethanol, 1-propanol, acetone, and chloroform were all small, and increased slightly with the increase of the temperature, respectively. Under the same temperature, the decrease order of solubility of norfloxacin in the different solvents is 1-propanol, chloroform, ethanol, and acetone. The experimental data were correlated with the modified Apelblat equation.