TiO2-SiO2 supports were prepared by various methods including precipitation, impregnation, hydrolysis-reflux and sol-gel, and then cobalt was impregnated on those supports. The properties of various catalysts were characterized by N-2 physisorption, XRD, XPS and TPR. The introduction of TiO2 led to stronger Co-support interaction, accompanying with the variation of dispersion and reduction degree of cobalt. The catalytic test for F-T synthesis revealed that the addition of TiO2 improved the performance of catalysts prepared by precipitation, impregnation and hydrolysis-reflux, but had a negative effect with sol-gel method.