Effective strategies are proposed in this paper to carry out the critical tasks in charging batch reactors under multiple constraints. Specifically, a target-setting procedure is presented to achieve a desired level of reliability. A synthesis method for building the optimal alarm logic is also described in detail. The monitoring systems constructed according to this suggested approach are effective in reducing the probability of undetected faulty batches. These techniques have been tested with extensive simulation studies. The results show that the proposed strategies are suitable for application if high-value-added products are manufactured in the plant, which in fact is a prevailing situation of the batch processes.