Chemistry Letters, Vol.38, No.9, 934-935, 2009
Stereocontolled Synthesis of (-)-Afzelechin: General Route to Catechin-class Polyphenols by Solving an S(N)2 vs. S(N)1 Problem
Stercocontrolled synthesis of (-)-afzelechin was achieved via the Mitsunobu reaction, where complete stereospecificity was observed when an electron-withdrawing group was introduced to the para-position of the B-ring fragment.