A new cembranoid, trocheliophorol (1), and a known cembranoid sarcophine have been isolated from the cultured soft coral Sarcophyton trocheliophorum. The structure of 1 was determined on the basis of extensive spectroscopic analysis. Compound 1 is the first alpha,beta-unsaturated-gamma-lactone cembrane that was found to possess a tetrahydrofuran moiety with an 8,11-ether linkage in a 14-membered ring.