Chemistry Letters, Vol.39, No.7, 676-677, 2010
Cucurbit[7]uril Inclusion Complexes of Platinum(II)-based Anticancer Drugs: Further Insight
The (HNMR)-H-1 characterization of the encapsulation of bisplatinum complex CT-3610 by cucurbit[7]uril is reported. The formation of the intermediate monoinclusion complex can be easily detected in the (HNMR)-H-1 spectrum, and the pD dependence of the equilibrium has also been assessed. No significant differences were observed in cytotoxicity experiments between the free and encapsulated form of CT-3610 on A2780 and cisplatin resistant A2780 human ovarian cancer cell lines.