Concentration time-histories were measured behind reflected shock waves during n-heptane oxidation for five species: n-heptane, C2H4, OH, CO2, and H2O. Experiments were conducted at temperatures of 1300-1600 K and a pressure of 2 atm using a mixture of 300 ppm n-heptane and 3300 ppm oxygen (phi = 1) in argon. n-Heptane and ethylene were monitored using IR gas laser absorption at 3.39 and 10.53 mu m, respectively; OH was monitored using UV laser absorption at 306.5 nm; and CO2 and H2O were monitored using tunable IR diode laser absorption at 2.7 and 2.5 mu m, respectively. These time-histories provide kinetic targets to test and refine large reaction mechanisms for n-heptane and demonstrate the potential of this type of data for validation of large reaction mechanisms. Comparisons are made with the predictions of several recently developed reaction mechanisms. (C) 2010 The Combustion Institute. Published by Elsevier Inc. All rights reserved.