We report a new nanocomposite catalytic cathode composed of iron phthalocyanine, platinum, carbon black and Nafion(R) (FePc-Pt/C-Nafion(R)) which exhibited enhanced catalytic activity for the oxygen reduction reaction (ORR) in the presence of methanol compared with usual Pt/C based electrodes. The catalytic cathode was prepared by depositing Pt colloidal nanoparticles (d(av) = 2.2 nm) on a FePc/C support to form a FePc-Pt/C powder and ultrasonically treating a mixture of Nafion(R) and the FePc-Pt/C powder in ethanol, followed by loading the mixture on a glassy carbon electrode and drying at 120 degrees C. In an O-2-saturated H2SO4 solution (0.5 M) with methanol (0.5 M), the onset potential (0.92 V vs RHE) over the FePc-Pt/C-Nafion(R) electrode shifted by more than 240 mV toward positive relative to that over an electrode prepared with a commercial Pt/C catalyst and Nafion(R). A new kind of catalytic sites constructed by FePc nanocrystals and Pt nanoparticles was found in the FePc-Pt/C-Nafion(R) electrode for the first time, which exhibited higher specific activity for ORR than Pt as calculated based on the hydrogen desorption charge. (C) 2010 Elsevier Ltd. All rights reserved.