Experiments were conducted to study the effect of mechanically induced fresh-air ventilation on the indoor air quality (IAQ) of the Tuskegee Healthy House (THH), selecting the outdoor weather conditions almost identical during the "fan OFF" and "fan ON" periods. Measurements of outdoor and indoor temperature and relative humidity (RH), in addition to the indoor dust particle concentration levels and interior wall moisture content, were systematically carried out during the summer month of August 2008. Results show that the effect of mechanically induced ventilation ("fan ON" period) is to raise the indoor RH, interior wall moisture content, and indoor dust particle concentration values significantly above those measured during the "fan OFF" period. The indoor temperature increases only slightly during the "fan ON" period. (C) 2009 Elsevier B.V. All rights reserved.