Heating, ventilating, and air conditioning (HVAC) systems comprise nearly one third of annual household energy consumption in the United States. HVAC energy use can be reduced by applying controls. This study applies a novel control method on a system with arbitrary steady-state and transient load distributions. The new method uses multi-dimensional interpolation between optimized control configurations for various steady-state load distributions. Demonstration of the new method on a two-room HVAC system predicts power savings for an arbitrary steady load that is nearly equivalent to that using a Variable-Air-Volume (VAV) with chiller modulation. However, the new method provides better energy savings for arbitrary transient loads: 19% energy savings over an uncontrolled system compared to energy savings of 6% for a VAV with chiller modulation. The average transient temperature deviation from setpoint using the new method is slightly better than that using VAV with chiller modulation. (C) 2010 Elsevier B.V. All rights reserved.