폴리(스티렌-이소부틸렌-스티렌) 삼중블록 공중합체의 합성, 분석 및 혈액적합성

Ping Ren; Yi-bo Wu; Wen-li Guo; Shu-xin Li; Jing Mao; Fei Xiao; Kang Li

Polymer(Korea), Vol.35, No.1, 40-46, January, 2011

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폴리(스티렌-이소부틸렌-스티렌) 삼중블록 공중합체의 합성, 분석 및 혈액적합성

Synthesis, Characterization and Haemocompatibility of Poly(styrene-b-isobutylene-b-styrene) Triblock Copolymers

Ping Ren^{1, 2}, Yi-bo Wu², Wen-li Guo^{2, †}, Shu-xin Li², Jing Mao³, Fei Xiao^{1, 2}, and Kang Li⁴

¹College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China
²Department of Material Science and Engineering, Beijing Institute of Petrochemical Technology, Beijing, 102617, China
³Key Laboratory for Synthetic Resin, Petrochemical Institute, Petrochina, 100195, China, Korea
⁴Department of Cardiology, Beijing Hospital, Beijing, 100730, China

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The synthesis of well-defined poly(styrene-b-isobutylene-b-styrene) (SIBS) triblock copolymers was accomplished by cationic sequential block copolymerization of isobutylene (IB) with styrene (St) using 1,4-di(2-chloro-2-propyl)benzene (DCC)/TiCl4 /2,6-di-tert-butylpyridine(DtBP) as an initiating system in methyl chloride (CH3Cl)/methylcyclohexane(MeChx) (50/50 v/v) solvent mixture at -80 ℃. The triblock copolymers exhibited excellent thermoplastic and elastomeric characteristics. Tensile strengths and Shore hardness increased with increasing polystyrene (PS) content, while elongation at break decreased. The blood-compatibility of SIBS was assessed by SEM observation of the platelet adhesion, blood clotting time and haemolysis ratio. The haemolysis ratios were below 5% which met the medical materials standard. The platelet adhesion test further indicated that SIBS block copolymers had a good blood compatibility.

Keywords:poly(styrene-b-isobutylene-b-styrene);haemocompatibility;thermoplastic elastomer;living/controlled cationic polymerization

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[1] Puskas JE, Chen YH, Dahman Y, Padavan D, J.Polym. Sci., Part A: Polym. Chem., 42, 3090 (2004)

[2] El Fray M, Prowans P, Puskas JE, Altstadt V, Biomacromolecules, 7(3), 844 (2006)

[3] Han J, Chen B, Ye L, Zhang AY, Zhang J, Feng ZG, Front. Mater. Sci. China., 3, 25 (2009)

[4] Silva GR, Silva-Cunha A, Behar-Cohen F, Ayres E, Orefice RL, Polym. Degrad. Stabil., 95, 491 (2010)

[5] Kamath KR, Barry JJ, Miller K, Adv. Drug Deliv. Rev., 58, 12 (2006)

[6] Moses J, Serruys PK, Fareed J, Textbook of Inter-Ventional Cardiovascular Pharmacology, Informa Healthcare, London, Boca Raton, FL, Taylor & Francis, p.299 (2007)

[7] Pinchuka L, Wilsonb GJ, Barryc JJ, Schoephoersterd RT, Parele JM, Kennedy JP, Biomaterials., 29, 448 (2008)

[8] Cadieux P, Watterson JD, Denstedt J, Harbottle RR, Puskas J, Howard J, Gan BS, Reid G, Colloids Surf. B., 28, 95 (2003)

[9] Storey RF, Lee YW, J. Macromol. Sci., Part A: Pure Appl. Chem., 29, 1017 (1992)

[10] Storey RF, Baugh DW, Choate KR, Polymer, 40(11), 3083 (1999)

[11] Zhou CR, Yi ZJ, Biomaterials., 20, 2093 (1999)

[12] Ferreira P, Coelho JFJ, Gil MH, Int. J. Pharm., 352, 172 (2008)

[13] Li LH, Tu M, Mou SS, Zhou CR, Biomaterials., 22, 2595 (2001)

[14] Tanaka M, Motomura T, Kawada M, Anzai T, Kasori Y, Shiroya T, Shimura KC, Onishi M, Mochizuki A, Biomaterials., 21, 1471 (2000)

[15] Li LH, Tu M, Mou SS, Zhou CR, Biomaterials., 22, 2595 (2001)

[16] Lee JH, Ju YM, Kim DM, Biomaterials., 21, 683 (2000)