A novel slurry catalyst for dehydration of methanol was prepared by complete liquid-phase technology. Its main innovative thought lies in preparing the slurry catalysts directly from solution. The catalysts were characterized using X-ray diffraction, Brunauer-Emmett-Teller, and NH3-TPD. It was found that the main crystal phase of slurry catalyst was boehmite AlO(OH). Also, it was observed that slurry catalyst had a high surface area and pore volume. Activity tests indicated that the slurry catalyst has shown better performance compared to the commercial -Al2O3: the highest methanol conversion was 84.4% at the temperature of 280 degrees C, dimethyl ether selectivity nearly reached 100%. The catalyst showed a good stability during the long-term test of 500 h.