A novel solvent, XDS, was developed to remove H2S, organic sulfur, and acid compounds in the crude high sour natural gas. Results showed that XDS solvent has a remarkable organic sulfur selectivity compared with the industrial conventional solvent, MDEA. Sulfur compound could reach 66.1 mg/m3 at 50% XDS solvent, gas to oil ratio 130 and 40 degrees C. The organic sulfur removing ratio of XDS could reach 93.7%, which is higher than MDEA by 30%. An absorption model was also developed to demonstrate that XDS solvent has a higher solubility and better mass transfer performance than MDEA.