In this communication, we report experimental dissociation conditions for region clathrate hydrates of methane + carbon dioxide in gas-liquid water-hydrate (G-Lw-H) equilibrium. The temperature and pressure conditions are in the range of (279.1-289.9)K and (2.96-13.06) MPa, respectively. Concentrations of carbon dioxide in the feed gas are also varied. An isochoric pressure-search method was used to perform the measurements. The dissociation data generated in this work along with the literature data are compared with the predictions of a thermodynamic model and a previously reported empirical equation. A discussion is made on the deviations between the experimental and predicted data. (c) 2010 Published by Elsevier B.V.