A four-zone flow boiling model is presented to describe saturated flow boiling heat transfer mechanisms in a microchannel of rectangular cross-section. The boiling process in the microchannel is assumed to be a cyclic passage of four zones: (i) liquid-slug zone, (ii) elongated bubble zone, (iii) partially-dryout zone, and (iv) fully-dryout zone. The existence of the partially-dryout zone in this model is proposed to take into consideration of corner effects on boiling heat transfer in the microchannel. To verify this new model, an experimental study was carried out to investigate flow boiling heat transfer of water in a microchannel having a rectangular cross-section with a hydraulic diameter of 137 mu m (202 mu m in width and 104 mu m in depth) with a length of 30 mm under three-side heating condition. The data for bubble nucleation frequency was correlated in terms of the Boiling number, which was used to determine the heat transfer coefficient. It is found that the present four-zone flow boiling model successfully predicts trends of boiling heat transfer data in a microchannel with a rectangular cross-section, having a sharp peak at low vapor quality depending on the mass flow rate. The predictions of flow boiling heat transfer coefficient in the microchannel are found in good agreement with experimental data with a MAE of 13.9%. (C) 2010 Elsevier Ltd. All rights reserved.