Segregation of granular materials by virtue of density or size is a commonly encountered phenomenon in nature. Despite its widespread interest among many researchers in recent years, a complete and unified understanding of granular segregation remains elusive to date. Using molecular dynamics simulations, we report a novel technique of inducing density segregation in a binary mixture of granular materials subjected to vibrations by the use of a bumpy vibrating base. Density segregation in the vertical directions may be induced by oscillating the bumpy base composed of discrete solid particles vertically or horizontally. In both cases, lighter particles tended to rise to the top of the granular bed and form a layer above the heavier particles. We suggest that differences in granular temperature profiles arising from the two different modes of vibrations may play an important role in determining the extent of density segregation occurring in binary granular mixtures. (C) 2010 American Institute of Chemical Engineers AIChE J, 56: 2588-2597, 2010