화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.35, No.2, 161-165, March, 2011
Export Citation
높은 안정성을 갖는 초미립 폴리에틸렌이민-금 나노입자
Ultrasmall Polyethyleneimine-Gold Nanoparticles with High Stability
김은정1, 염정현1, 2, †, 김한도1, 3, 이세근4, 이가현4, 이현주4, 한상익5, 최진현1, 2, †
  • 1경북대학교 기능물질공학과
  • 2경북대학교 천연섬유학과
  • 3경북대학교 섬유시스템공학과
  • 4대구경북과학기술원 나노바이오연구부
  • 5국립식량과학원 기능성작물부 신소재개발과
Eun Jung Kim1, Jeong Hyun Yeum1, 2, †, Han Do Ghim1, 3, Se Guen Lee4, Ga Hyun Lee4, Hyun Ju Lee4, Sang Ik Han5, and Jin Hyun Choi1, 2, †
  • 1Department of Advanced Organic Materials Science and Engineering, Kyungpook National University, Daegu 702-701, Korea
  • 2Department of Natural Fiber Science, Kyungpook National University, Daegu 702-701, Korea
  • 3Department of Textile System Engineering, Kyungpook National University, Daegu 702-701, Korea
  • 4Division of Nano & Bio Technology, Daegu Gyungbuk Institute of Science & Technology, Daegu 711-873, Korea
  • 5Division of Functional Crop Resource Development, Department of Functional Crop, National Institute of Crop Science, Miryang 627-803, Korea
E-mail:,
초록
본 연구는 수계에서 오랜 시간 동안 안정한 생체적합 금 나노입자의 제조에 관한 것으로, 환원제와 안정제의 역할을 동시에 수행하는 폴리에틸렌이민을 이용하여 응집성이 낮은 초미립 폴리에틸렌이민-금 나노입자를 상온의 수용액 상에서 합성하였다. 폴리에틸렌이민-금 나노입자의 평균 입자크기는 8∼12 nm이었고, 수계의 나노콜로이드 상에서 50 nm 내외의 클러스터를 형성하였으며, 매우 뛰어난 안정성을 보였다. 상대적으로 낮은 금속 전구체의 농도에서 나노입자를 제조하였을 때, 입자의 크기가 두드러지게 감소하는 경향을 나타내었다. 폴리에틸렌이민-금 나노입자의 X-선 회절분석 결과, 금에서 나타나는 전형적인 결정 피크가 발견되었다. 또한 세포배양실험 결과, 폴리에틸렌이민과는 달리 폴리에틸렌이민-금 나노입자는 98%의 세포 생존율을 보여 세포독성은 거의 없는 것으로 나타났다. 이상의 결과로부터 본 연구에서 합성된 폴리에틸렌이민-금 나노입자는 CT 조영제 등으로의 활용이 기대된다.
This study is related to the preparation of biocompatible gold nanoparticles (AuNPs) which are stable in aqueous solutions for a long time. Ultrasmall polyethyleneimine (PEI)-capped AuNPs (PEIAuNPs) with limited agglomeration were prepared in aqueous solutions at room temperature, which were based on the roles of PEI as a reductant and a stabilizer. PEI-AuNPs with an average size of 8∼12 nm formed highly stable nanocolloids with an average hydrodynamic cluster size of around 50 nm in aqueous media. At a low concentration of metal precursor hydrogen tetrachloroaurate(III), the particle size was reduced noticeably. The typical peaks of gold were observed in the X-ray diffraction pattern of AuNPs. The cell viability of 98% was obtained in the case of PEI-AuNPs, while PEI was cytotoxic. The PEI-AuNP is considered to be a potential candidate as a contrast agent for computed tomography.
Keywords:gold;nanoparticles;polyethyleneimine;reductant;stabilizer.
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