Values of density, ultrasonic speed, and viscosity of salbutamol sulphate (SBS) have been determined in aqueous methanol solutions at T = (303.15, 308.15, 313.15, and 318.15) K. The apparent molar volume V phi, partial molar volume V phi(0) molar expansivity E-2(0), isobaric thermal expansion coefficient (alpha(2)), and second derivative of infinite dilution of partial molar volume with temperature partial derivative V-2(phi)0/partial derivative T-2 are evaluated using density data. Isentropic compressibility beta(s), change in isothermal compressibility Delta beta(s), relative change in isentropic compressibility (Delta beta/beta(0)(s)), apparent molar compressibility K-phi and partial molar compressibility K-phi(0) values are calculated by using data on density with ultrasonic speed. Viscosity B-coefficient, variation of B-coefficient with temperature, i.e., dB/dT. free energy of activation per mole of solvent Delta mu(0)(l). and solute Delta mu(0)(2). are evaluated using viscosity data. The above parameters are used to interpret the solute-solute, solute-solvent interactions and structure making/breaking ability of the drug in the given aqueous methanol solution. (C) 2010 Elsevier Ltd. All rights reserved.