Balanites aegyptiaca is a naturally grown desert plant at some radioactive places in Wadi El-Gemal area, Southeastern Desert. The aim of the present study was to highlight on the B. aegyptiaca species grown naturally at radioactive places in Wadi El-Gemal area (fruit part) on the ability of using the fruit in some biomedical application (glucose, cholesterol, triglycerides, HDL-cholesterol. LDL-cholesterol and diabetes). The investigated plant was collected from different location at Wadi El-Gemal area. The uranium content was determined previously and different concentrations from the fruit with highest uranium content were used to examine the effect of B. aegyptiaca (fruit part) on the glucose, triglycerides, total cholesterol (HDL and LDL-cholesterol) levels using experimental rats. Different analysis techniques were used in order to determine different parameters. The obtained data suggest the beneficial role of B. aegyptiaca fruit as an anti-diabetic and hypo-lipidimic agent. (C) 2010 Elsevier B.V. All rights reserved.