Batch biosorption experiments have been carried out for the removal of bovine serum albumin (BSA) from simulated industrial wastewater onto Ulva lactuca seaweed. Various vital parameters influencing the biosorption process such as initial concentration of BSA. pH of the solution, adsorbent dosage and temperature have been determined. The biosorption kinetics follows a pseudo-second order kinetic model. Equilibrium isotherm studies demonstrate that the biosorption followed the Freundlich isotherm model, which implies a heterogeneous sorption phenomenon. Various thermodynamic parameters such as changes in enthalpy, free energy and entropy have been calculated. The positive value of Delta H degrees and the negative value of Delta G degrees show that the sorption process is endothermic and spontaneous. The positive value of change in entropy Delta S degrees shows increased randomness at the solid-liquid interface during the biosorption of BSA onto U. lactuca seaweed. (C) 2010 Elsevier B.V. All rights reserved.