The generalized Newtonian fluid, as an important kind of non-Newtonian fluids, has been widely used in both science and engineering. In this paper, we present a multiple-relaxation-time lattice Boltzmann model for generalized Newtonian fluid, and validate the model through a detailed comparison with analytical solutions and some published results. The accuracy and stability of the present model are also studied, and compared with those of the popular single-relaxation-time lattice Boltzmann model. Finally, the limit and potential of the multiple-relaxation-time lattice Boltzmann model are briefly discussed. (C) 2011 Elsevier B.V. All rights reserved.