Journal of the American Chemical Society, Vol.132, No.33, 11418-11419, 2010
Enantioselective Construction of Spiroindolenines by Ir-Catalyzed Allylic Alkylation Reactions
With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,R-a)-L-6, Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92-98% yields with up to >99/1 dr and 97% ee.