Journal of the American Chemical Society, Vol.132, No.45, 15836-15838, 2010
Enantioselective [2+2+2] Cycloaddition Reaction of Isocyanates and Allenes Catalyzed by Nickel
The enantioselective intermolecular [2 + 2 + 2] cycloaddition reaction of two molecules of isocyanate and one molecule of allene is catalyzed by a nickel(0)/(S,S)-i-Pr-FOXAP complex, providing an efficient access to enantiomerically enriched dihydropyrimidine-2,4-diones.