Journal of the American Chemical Society, Vol.132, No.46, 16374-16376, 2010
Enantioselective Copper-Catalyzed Intramolecular O-H Insertion: An Efficient Approach to Chiral 2-Carboxy Cyclic Ethers
A copper-catalyzed asymmetric intramolecular O-H insertion of omega-hydroxy-alpha-diazoesters has been accomplished by using chiral spiro bisoxazoline ligands. This highly enantioselective intramolecular O-H insertion reaction provides an efficient approach to a variety of synthetically important chiral 2-carboxy cyclic ethers with different ring sizes as well as substitution patterns.