Electroosmotic pumps are arguably the simplest of all pumps, consisting merely of two flow-through electrodes separated by a porous membrane. Most use platinum electrodes and operate at high voltages, electrolyzing water. Because evolved gas bubbles adhere and block parts of the electrodes and the membrane, steady pumping rates are difficult to sustain. Here we show that when the platinum electrodes are replaced by consumed Ag/Ag2O electrodes, the pumps operate well below 1.23 V, the thermodynamic threshold for electrolysis of water at 25 degrees C, where neither H-2 nor O-2 is produced. The pumping of water is efficient: 13 000 water molecules are pumped per reacted electron and 4.8 mL of water are pumped per joule at a flow rate of 0.13 mL min(-1) V-1 cm(-2), and a flow rate per unit of power is 290 mL min(-1) W-1. The water is driven by protons produced in the anode reaction 2Ag(s) + H2O -> Ag2O(s) + 2H(+) + 2e(-), traveling through the porous membrane, consumed by hydroxide ions generated in the cathode reaction Ag2O(s) + 2 H2O + 2e(-) -> 2Ag(s) + 2 OH-. A pump of 2 mm thickness and 0.3 cm(2) cross-sectional area produces flow of 5-30 mu L min(-1) when operating at 0.2-0.8 V and 0.04-0.2 mA. Its flow rate can be either voltage or current controlled. The flow rate suffices for the delivery of drugs, such as a meal-associated boli of insulin.