Pdnp and Pd containing trimetallic nanoparticles (tnp) are synthesized by chemical method with cetyltrimethylammonium bromide as the capping agent. Compositionally, four different tnp are prepared and the particle sizes are characterized by UV-vis spectra, HR-TEM, and XRD measurements. The catalytic activities of Pdnp and tnp are tested using the Sonogashira C-C coupling reaction. The product yield and recyclability of the recovered catalysts are studied. tnp (1:1:1) exhibited better catalysis than Pdnp, which may be due to the concerted electronic effects of the Au-Ag core onto the Pd shell atoms.