Poly(ethylene glycol)-block-poly(acrylic acid) (PEG-PAA) is modified by 3-aminophenylboronic acid (APBA) with different modification degrees, such as PEG(114)-b-(PAA(0.37)-co-PAAPBA(0.63))(170), PEG(114)-b-(PAA(0.23)-co-PAAPBA(0.77))(170) and PEG(114)-b-(PAA(0.02)-co-PAAPBA(0.98))(170). Micelles self-assembled from these three copolymers possess glucose-responsiveness at varying pH values. Micelles self-assembled from PEG(114)-b-(PAA(0.37)-co-PAAPBA(0.63))(170) have glucose-responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. 11 B magic-angle spinning nuclear magnetic resonance (B-11 MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose-responsiveness of PEG(114)-b-(PAA(0.37)-co-PAAPBA(0.63))(170) micelles at pH 7.4.