Porcine amniotic fluid as possible antiwrinkle cosmetic agent

Tagon Kim; Sung Kim; WhanYul Kang; Hyun Baek; Hye Young Jeon; Bo Young Kim; Chun Gyu Kim; Donguk Kim

Korean Journal of Chemical Engineering, Vol.28, No.9, 1839-1843, September, 2011

DOI10.1007/s11814-011-0047-z Export Citation

Porcine amniotic fluid as possible antiwrinkle cosmetic agent

Tagon Kim, Sung Kim, WhanYul Kang¹, Hyun Baek¹, Hye Young Jeon¹, Bo Young Kim¹, Chun Gyu Kim, and Donguk Kim^†

Department of Pharmaceutical Engineering, Inje University, Gimhae, Gyongnam 621-749, Korea
¹Amaranth Cosmetics, 1534-2, Songjung-dong, Gangseo-gu, Busan 618-817, Korea

E-mail:

Porcine amniotic fluid was investigated for use as a functional cosmetic ingredient. From safety tests by MTT (5-diphenyltetrazolium bromide) assay, cell viability was above 90% for 50-1,000 μg/mL concentration and porcine amniotic fluid was safe for cosmetic ingredient. From stability tests, cream containing 1% porcine amniotic fluid maintained constant physical properties for color, pH and viscosity during 28 days, and porcine amniotic fluid was stable for a cosmetic agent. Efficacy tests were done for antiwrinkle (elastase inhibition and collagenase synthesis inhibition), whitening (tyrosinase inhibition and DOPA (3,4-Dihydroxy-L-phenyl-alanine) oxidation inhibition) and antioxidation. At 500 μg/mL concentration, elastase inhibition of porcine placenta amniotic fluid was 33%, whereas that of adenosine as reference was 14%. However, porcine amniotic fluid showed relatively insignificant effect on collagenase synthesis inhibition, whitening and antioxidation activity. From this study, porcine amniotic fluid showed potential for a future antiwrinkle cosmetic agent.

Keywords:Porcine Amniotic Fluid;Antiwrinkle;Whitening;Safety;Stability

[References]

Korea Food and Drug Administration, http://www.kfda.go.kr/index. html. (2009)
Cosmetics Industry Analysis Report 2009, KHIDI, Seoul (2009)
Elsner P, Mailbach HI, Cosmeceuticals and active cosmetics, 2nd Ed., Taylor & Francis, New York (2005)
Ha BC, Cosmeceuticals, Shin Kwang Publishing, Seoul (2005)
KDA Textbook Editiong Board, Dermatology, 5th Ed., Ryo Mook-Gak, Seoul (2008)
Vielhaber G, Schmaus G, Jacobs K, Franke H, Lange S, Hermann M, Joppe H, Koch O, IFSCC., 9, 227 (2006)
Park SH, Lee BY, Han CS, Kim JG, Kim KT, Kim KH, Kim YH, J. Soc. Cosmet. Scientists Korea., 33, 101 (2007)
Pillai R, Redmond M, Roding J, IFSCC., 8, 17 (2005)
Park JC, Herbal functional food, Hyoilbooks, Seoul (2007)
Zheng YM, Zhao HY, Zhao XE, Quan FS, Hua S, He XY, Liu J, He XN, Lin H, Reproduction., 137, 793 (2009)
Kim BY, Kim T, Kang WY, Hyun B, Cheon HY, Kim D, Korean Chem. Eng. Res., 48(3), 327 (2010)
Ozqenel GY, Samil B, Ozcan M, J. Hand Surgery., 26, 332 (2001)
Mosmann T, J. Immun. Method., 65, 55 (1983)
Erdemogu N, Sener B, Ide S, J. Mol. Struct., 559, 227 (2001)
Yagi A, Kanbara T, Morinobu N, Plantamedica., 3981, 517 (1986)
Fujita Y, Hehara I, Morimoto Y, Nakashima M, Hatano T, Okuda T, YakugakuZasshi., 108, 129 (1988)
Kim T, Master’s Thesis, Inje University, Gimhae, Korea (2011)
Kim HJ, Kim T, Kang WY, Hyun B, Cheon HY, Kim BY, Kim D, Korean Chem. Eng. Res., 48(4), 413 (2010)
Lee KH, Park SN, J. Soc. Cosmet. Scientists Korea., 34, 25 (2008)
Kim MJ, Lim KR, Jung TK, Yoon KS, J. Soc. Cosmet. Scientists Korea., 33, 33 (2007)
Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea., 33, 165 (2007)

[Referenced By]

[Related Articles]

[1] Korea Food and Drug Administration, http://www.kfda.go.kr/index. html. (2009)

[2] Cosmetics Industry Analysis Report 2009, KHIDI, Seoul (2009)

[3] Elsner P, Mailbach HI, Cosmeceuticals and active cosmetics, 2nd Ed., Taylor & Francis, New York (2005)

[4] Ha BC, Cosmeceuticals, Shin Kwang Publishing, Seoul (2005)

[5] KDA Textbook Editiong Board, Dermatology, 5th Ed., Ryo Mook-Gak, Seoul (2008)

[6] Vielhaber G, Schmaus G, Jacobs K, Franke H, Lange S, Hermann M, Joppe H, Koch O, IFSCC., 9, 227 (2006)

[7] Park SH, Lee BY, Han CS, Kim JG, Kim KT, Kim KH, Kim YH, J. Soc. Cosmet. Scientists Korea., 33, 101 (2007)

[8] Pillai R, Redmond M, Roding J, IFSCC., 8, 17 (2005)

[9] Park JC, Herbal functional food, Hyoilbooks, Seoul (2007)

[10] Zheng YM, Zhao HY, Zhao XE, Quan FS, Hua S, He XY, Liu J, He XN, Lin H, Reproduction., 137, 793 (2009)

[11] Kim BY, Kim T, Kang WY, Hyun B, Cheon HY, Kim D, Korean Chem. Eng. Res., 48(3), 327 (2010)

[12] Ozqenel GY, Samil B, Ozcan M, J. Hand Surgery., 26, 332 (2001)

[13] Mosmann T, J. Immun. Method., 65, 55 (1983)

[14] Erdemogu N, Sener B, Ide S, J. Mol. Struct., 559, 227 (2001)

[15] Yagi A, Kanbara T, Morinobu N, Plantamedica., 3981, 517 (1986)

[16] Fujita Y, Hehara I, Morimoto Y, Nakashima M, Hatano T, Okuda T, YakugakuZasshi., 108, 129 (1988)

[17] Kim T, Master’s Thesis, Inje University, Gimhae, Korea (2011)

[18] Kim HJ, Kim T, Kang WY, Hyun B, Cheon HY, Kim BY, Kim D, Korean Chem. Eng. Res., 48(4), 413 (2010)

[19] Lee KH, Park SN, J. Soc. Cosmet. Scientists Korea., 34, 25 (2008)

[20] Kim MJ, Lim KR, Jung TK, Yoon KS, J. Soc. Cosmet. Scientists Korea., 33, 33 (2007)

[21] Kim JY, Yang HJ, Lee KH, Jeon SM, Ahn YJ, Won BR, Park SN, J. Soc. Cosmet. Scientists Korea., 33, 165 (2007)