Modeling and simulation of tanks-in-series airlift bioreactors for production of lactic acid by fermentation

Leila Vafajoo; Houman Savoji; Roozbeh Fayal; Ali Baghaei

Korean Journal of Chemical Engineering, Vol.28, No.8, 1727-1735, August, 2011

DOI10.1007/s11814-011-0062-0 Export Citation

Modeling and simulation of tanks-in-series airlift bioreactors for production of lactic acid by fermentation

Leila Vafajoo^†, Houman Savoji¹, Roozbeh Fayal², and Ali Baghaei³

Chemical and Environmental Engineering Group, Islamic Azad University, South Tehran Branch, Tehran, Iran
¹Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran
²Biotechnology Group, Engineering Faculty, Azad University of Science & Research, Tehran, Iran
³Department of Chemical Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran

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A tanks-in-series model was applied for mathematical modeling of the unsteady state performance of 70 and 100 liters airlift bioreactor for the production of lactic acid by fermentation. A set of first-order differential equations for the material balances of micro-organism, substrate, product, and dissolved oxygen around hypothetically well mixed stages was solved simultaneously utilizing computer program in MATLAB. The kinetic model utilized considered the effect of two substrates (glucose and dissolved oxygen) on the growth rate. The effect of air velocity on the lactic acid production was investigated. Results of this model have been validated with experimental data.

Keywords:Airlift Bioreactor;Lactic Acid;Dissolved Oxygen;Modeling;Bioreactors

[References]

Merchuk JC, in: Scuger K (Ed.), Biotechnology, Second Ed., VCH, Weinheim (1993)
Williams JA, Keys to bioreactor selections., 12, 34 (2002)
Datta R, Tsai SP, Bonsignore P, Moon SH, Frank JR, Microbiol. Rev., 16, 221 (1995)
Luttman R, Thoma M, Buchholz H, Schugerl K, Comput. Chem. Eng., 7, 43 (1983)
Luttman R, Thoma M, Buchholz H, Schugerl K, Comput. Chem. Eng., 7, 51 (1983)
Merchuk JC, Stein Y, Mateles RI, Biotechnol. Bioeng., 22, 1189 (1980)
Aghamiri ZS, Mehrnia MR, Fatemi S, Shojaosadati SA, Yazdian F, Process Biochem., 45, 1393 (2010)
Andre G, Robinson CW, Young MM, Chem. Eng. Sci., 38, 1845 (1983)
Pigache S, Trystram G, Dhoms P, Biotechnol. Bioeng., 39, 923 (1992)
Turner JR, Mills PL, Chem. Eng. Sci., 45, 2317 (1990)
Jia XQ, Wen JP, Jiang Y, Liu XL, Feng W, Chem. Eng. Sci., 61(11), 3463 (2006)
Andre G, Robinson CW, Young MM, Chem. Eng. Sci., 38, 1845 (1983)
Miura S, Arimura T, Hoshino M, Kojima M, Dwiarti L, Okabe M, J. Biosci. Bioeng., 96(1), 65 (2003)
Fayal R, Modeling and simulation of an airlift bioreactor including a biochemical reaction, MSc Thesis, Islamic Azad University, Tehran, Iran (2007)
Chisti Y, Airlift Bioreactors, Elsevier, London (1989)
Leven spiel, Chem. React. Eng., John Wiley (1999)

[Referenced By]

[1] Merchuk JC, in: Scuger K (Ed.), Biotechnology, Second Ed., VCH, Weinheim (1993)

[2] Williams JA, Keys to bioreactor selections., 12, 34 (2002)

[3] Datta R, Tsai SP, Bonsignore P, Moon SH, Frank JR, Microbiol. Rev., 16, 221 (1995)

[4] Luttman R, Thoma M, Buchholz H, Schugerl K, Comput. Chem. Eng., 7, 43 (1983)

[5] Luttman R, Thoma M, Buchholz H, Schugerl K, Comput. Chem. Eng., 7, 51 (1983)

[6] Merchuk JC, Stein Y, Mateles RI, Biotechnol. Bioeng., 22, 1189 (1980)

[7] Aghamiri ZS, Mehrnia MR, Fatemi S, Shojaosadati SA, Yazdian F, Process Biochem., 45, 1393 (2010)

[8] Andre G, Robinson CW, Young MM, Chem. Eng. Sci., 38, 1845 (1983)

[9] Pigache S, Trystram G, Dhoms P, Biotechnol. Bioeng., 39, 923 (1992)

[10] Turner JR, Mills PL, Chem. Eng. Sci., 45, 2317 (1990)

[11] Jia XQ, Wen JP, Jiang Y, Liu XL, Feng W, Chem. Eng. Sci., 61(11), 3463 (2006)

[12] Andre G, Robinson CW, Young MM, Chem. Eng. Sci., 38, 1845 (1983)

[13] Miura S, Arimura T, Hoshino M, Kojima M, Dwiarti L, Okabe M, J. Biosci. Bioeng., 96(1), 65 (2003)

[14] Fayal R, Modeling and simulation of an airlift bioreactor including a biochemical reaction, MSc Thesis, Islamic Azad University, Tehran, Iran (2007)

[15] Chisti Y, Airlift Bioreactors, Elsevier, London (1989)

[16] Leven spiel, Chem. React. Eng., John Wiley (1999)