Various morphologies including spherical micelles, nanowires and vesicles have been prepared by reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization of styrene (St) in methanol using S-1-dodecyl-S -(alpha,alpha'-dimethyl-alpha ''-acetic acid) trithiocarbonate (TC)-terminated poly (ethylene oxide) (PEO-TC) and 2,2'-azobis(isobutyronitrile) (AIBN) as chain transfer agent and initiator, respectively. GPC, H-1 NMR, TEM and laser light scattering (LLS) were used to track the polymerization. The results showed that the block copolymers PEO-b-polystyrene (PEO-b-PS) were formed firstly in homogenous polymer solution, and then the spherical micelles were produced via polymerization-induced self-assembling. Continuous polymerization of the PS blocks induced the transition of spherical micelles into other morphologies. The polymerization-induced self-assembling and reorganization (PISR) were induced by chain length ratio increase of PS to PEO blocks. The concentration of St in methanol is also important factor to influence the formation of morphologies. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.