Mixed plutonium and uranium monocarbide (UPuC) is considered as a possible fuel material for future nuclear gas fast reactors. Its safe handling is currently a major concern, because inflammation of this material under the shape of fine powders is easy and highly exothermic (pyrophoricity) even under ambient temperature and partial pressure of oxygen inferior to 0.2 bar. CEA Marcoule is implied in both experimental and numerical studies on the UC powder oxidation exothermic reaction. Experimental tests consist in determining the influence of various parameters (gas composition, heating ramp, specific surface of powders) on the sample inflammation temperature. Two kinds of analytical apparatus are used: The differential thermal analysis (DTA) and the differential scanning calorimetry (DSC) coupled to the thermo gravimetric analysis (TGA). These apparatus are also linked to a gas mass spectrometer to follow the composition of combustion chamber gases. Results obtained with small quantities revealed that UC powder is highly reactive in air in the temperature range of 150-250 degrees C and showed a strong dependence between powder height in crucibles and inflammation temperature. (C) 2010 Elsevier B.V. All rights reserved.